FIELD: biochemistry.
SUBSTANCE: invention is related to an isolated antibody to RGMa or its antigen-binding fragment. A nucleic acid molecule encoding said antibody; an expression vector containing said nucleic acid molecule; a host cell containing said vector; a composition containing said antibody are also disclosed. A method for producing said antibody is disclosed.
EFFECT: invention makes it possible to effectively treat diseases in which the activity of RGMa is involved.
14 cl, 18 ex, 3 tbl, 6 dwg
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