FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry, in particular to an isolated antibody or its antigen-binding fragment, which specifically bind to the C5a human complement receptor C5aR. Also disclosed is an isolated nucleic acid molecule coding said antibody; an expression vector and a host cell containing said nucleic acid molecule; pharmaceutical composition containing said antibody. Disclosed is a method of producing said antibody.
EFFECT: invention makes it possible to effectively treat diseases associated with C5aR.
18 cl, 18 ex, 23 tbl, 11 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-PCSK9 ANTIBODY, ITS ANTIGEN-BINDING DOMAIN AND MEDICAL APPLICATION THEREOF | 2016 |
|
RU2739208C2 |
| ANTIBODY TO B7-H4, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE | 2019 |
|
RU2792748C2 |
| COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUS | 2015 |
|
RU2764981C1 |
| AMATOXIN ANTIBODY-DRUG CONJUGATES AND USE THEREOF | 2020 |
|
RU2826004C2 |
| Therapeutic antibodies to CD47 | 2016 |
|
RU2748401C2 |
| FUSED PROTEIN CONSTRUCTS FOR COMPLEMENT-RELATED DISEASE | 2019 |
|
RU2824402C2 |
| ANTIBODIES CONTAINING POLYPEPTIDE INTEGRATED INTO FRAME REGION 3 | 2019 |
|
RU2796254C2 |
| ANTIBODY TO TIGIT AND ITS USE | 2019 |
|
RU2786434C2 |
| ANTIBODY AGAINST SIRPα | 2019 |
|
RU2791002C2 |
| BISPECIFIC ANTIBODY AGAINST RABIES VIRUS AND ITS APPLICATION | 2019 |
|
RU2764740C1 |
