FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and genetic engineering, particularly to methods for genetic modification of hematopoietic cells. Presented is the use of prostaglandin E2 (PGE2), poloxamer and protamine sulphate for enhancing transduction by a recombinant retroviral vector.
EFFECT: compositions and methods according to the present invention can be used in gene therapy, including treatment of monogenic genetic diseases and disorders.
54 cl, 18 dwg, 2 tbl, 5 ex
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