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2 826 247

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IPC

C07K14/315(2006-01-01)

C07K14/76(2006-01-01)

A61K51/08(2006-01-01)

A61K103/30(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2023129424, 2023-11-14

(24)

Start date

2023-11-14

(22)

Actual filing date

2023-11-14

(45)

Published

2024-09-06

(72)

Inventor

Tolmachev Vladimir MaksimilianovichIusubov Mekhman Suleiman OglyChernov Vladimir IvanovichDeev Sergei Mikhailovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Issledovatelskii Tomskii Politekhnicheskii Universitet"

COMPOUND AND ITS COMPLEX WITH RADIONUCLIDE Lu FOR THERANOSTICS OF TUMORS EXPRESSING ON HER2 RECEPTORS Russian patent published in 2024 - IPC C07K14/315 C07K14/76 A61K51/08 A61K103/30 A61P35/00

Abstract RU 2826247 C1

FIELD: organic chemistry; medical chemistry; oncology.

SUBSTANCE: invention relates to the field of radiopharmaceuticals intended for use as theranostic agents for diagnostics and therapy of tumors expressing on HER2 receptors. Disclosed is a compound for producing a complex with a radionuclide label for theranostics of tumors with hyperexpression of epidermal growth factor type 2 (HER2) of general formula ADAPT6-(SSSG)3-ABD035-GSSC-DOTAGA and a complex comprising a compound according to claim 1 with radionuclide mark, which is ¹⁷⁷Lu radionuclide.

EFFECT: wider range of theranostic agents for selective targeting and penetration into pathogenic tumor tissues, with optimal characteristics for targeted radionuclide therapy of tumors with hyperexpression of epidermal growth factor type 2 (HER2).

2 cl, 2 ex

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RU 2 826 247 C1

Authors

Tolmachev Vladimir Maksimilianovich

Iusubov Mekhman Suleiman Ogly

Chernov Vladimir Ivanovich

Deev Sergei Mikhailovich

Dates

2024-09-06—Published

2023-11-14—Filed