FIELD: biotechnology.
SUBSTANCE: present application relates to biotechnology and can be used in medicine. More specifically, the present invention relates to an isolated codon-optimized nucleic acid which codes a FIX (blood coagulation factor IX) protein, an expression cassette and a vector based thereon, as well as to a recombinant virus based on AAV5 (serotype 5 adeno-associated virus) for increasing FIX gene expression in target cells and their use.
EFFECT: disclosed is a codon-optimized nucleic acid which codes a coagulation factor protein ix, and its use.
10 cl, 5 ex, 1 tbl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| AAV5-BASED VACCINE FOR INDUCTION OF SPECIFIC IMMUNITY TO SARS-COV-2 VIRUS AND/OR PREVENTION OF CORONAVIRUS INFECTION CAUSED BY SARS-COV-2 | 2020 |
|
RU2760301C1 |
| VACCINE BASED ON AAV5 FOR INDUCTION OF SPECIFIC IMMUNITY TO SARS-CoV-2 VIRUS AND/OR PREVENTION OF CORONAVIRUS INFECTION CAUSED BY SARS-CoV-2 | 2020 |
|
RU2783313C1 |
| VACCINE BASED ON AAV5 FOR THE INDUCTION OF SPECIFIC IMMUNITY TO THE SARS-CoV-2 VIRUS AND/OR THE PREVENTION OF CORONAVIRUS INFECTION CAUSED BY SARS-CoV-2 | 2021 |
|
RU2761879C1 |
| MODIFIED FACTOR IX, AS WELL AS COMPOSITIONS, METHODS AND OPTIONS FOR THE USE OF GENE TRANSFER INTO CELLS, ORGANS AND TISSUE | 2016 |
|
RU2811445C2 |
| ISOLATED MODIFIED VP1 CAPSID PROTEIN OF ADENO-ASSOCIATED VIRUS OF SEROTYPE 5 (AAV5), CAPSID AND VECTOR BASED ON IT | 2019 |
|
RU2751592C2 |
| METHOD OF PRODUCING MODIFIED CAPSID OF ADENO-ASSOCIATED VIRUS | 2021 |
|
RU2831732C1 |
| VERSION OF AAV, COMPOSITIONS AND METHODS IN WHICH IT IS USED, AS WELL AS METHODS OF USING IT FOR TRANSFERRING GENES INTO CELLS, ORGANS AND TISSUES | 2014 |
|
RU2837753C2 |
| RECOVERED NUCLEIC ACID WHICH CODES FVIII-BDD-BASED FUSION PROTEIN AND HETEROLOGOUS SIGNAL PEPTIDE, AND USE THEREOF | 2022 |
|
RU2818229C2 |
| RECOMBINANT AAV VECTORS EXPRESSING OSTEOPROTECTIVE GENES, INCLUDING HAS2 AND LUBRICIN, SUITABLE IN TREATMENT OF OSTEOARTHRITIS AND SIMILAR JOINT DISEASES IN MAMMALS | 2017 |
|
RU2771490C2 |
| CODON-OPTIMIZED NUCLEIC ACID THAT ENCODES B-DOMAIN-DELETED FACTOR VIII PROTEIN AND ITS USE | 2022 |
|
RU2808564C2 |
