FIELD: medicine.
SUBSTANCE: present invention refers to medicine, particularly to oncology and laboratory and medical genetics. Present invention is a set (panel) of primers for high-throughput sequencing of target gene regions AKT1, ALK, APC, BRAF, CDH1, CDKN2A, CTNNB1, DDR2, EGFR, EIF1AX, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, FOXL2, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HIST1H3C, HNF1A, HRAS, IDH1, IDH2, KDR, KIT, KRAS, MAP2K1, MET, MLH1, NRAS, PDGFRA, PIK3CA, PTEN, RET, ROS1, SF3B1, SMAD4, SMARCB1, SMO, SRC, STK11, TERT, TP53, TSC1, VHL. Disclosed is the use of a kit for detecting clinically significant genetic variants (in particular, somatic mutations) in tumour tissue samples in order to clarify the diagnosis and prognosis of the oncological disease and in order to further adjust the treatment plan, including for the purpose of selecting the optimal anti-tumour targeted therapy.
EFFECT: present invention provides higher quality and efficiency of molecular diagnostics of solid tumours.
3 cl, 2 tbl
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RU2829344C1 |
