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Application

4603902/04, 1988-11-09

(22)

Actual filing date

1988-11-09

(45)

Published

1994-10-15

(72)

Inventor

Tjukhteneva Z.I.Badovskaja L.A.Vas'Kov K.S.Mingalev A.N.Bartashevich V.V.Galenko-Jaroshevskij P.A.Budarin L.I.Kriss E.E.Grebennikov V.N.

3-(3-HYDROXYAMINOPROPYL)-4-HYDROXYBUTYRATE SODIUM SHOWING ANTINECROTIC AND CARDIOTROPIC ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1610818 A1

FIELD: organic chemistry, amides of carboxylic acids. SUBSTANCE: synthesis is carried out by reaction of 3-(3-hydroxyaminopropyl)- 4-hydroxy-N-(3-hydroxyaminopropyl)butaneamide with sodium hydroxide in aqueous- spirituous medium. Yield is 76% , m. p. is 324-325 C, gross-formula is C7H14NO4Na. New compound at doses 25, 50 and 100 mg/kg increases volume rate of coronary circulation by 38.9; 91.4 and 94.0%, respectively (comparison at the sixth minute after administration). EFFECT: enhanced activity of product. 4 tbl

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SU 1 610 818 A1

Authors

Tjukhteneva Z.I.

Badovskaja L.A.

Vas'Kov K.S.

Mingalev A.N.

Bartashevich V.V.

Galenko-Jaroshevskij P.A.

Budarin L.I.

Kriss E.E.

Grebennikov V.N.

Dates

1994-10-15—Published

1988-11-09—Filed

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