METHOD OF PRODUCING DERIVATIVES OF OXADIAZOLALKYLPURINE OR ITS PHARMACEUTICALLY AVAILABLE ACID ADDITIVE SALTS ( AND VARIANTS OF THIS METHOD ) Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: desired product is derivative of oxadiazole having formula 1 where A is C₁-C₄R′-alkylene, R-C₁-C₄-alkyl, oxy-or chlor, or carboxy ( lower ) alkyl, cyclohexyl, phenyl, oxyphenyl, carboxyphenyl, benzyl, dimethoxybenzyl, or aminoalyl having formula (CH₂)_nNR²R³ where n= 1-3, R and R⁵ are C₁-C₄-alkal or together with nitrogen they form piperidine or morpholine ring or its pharmaceutically available acid-additive salts. According to the first variant oxime having formula 2 interacts with lower alkyl ester of R-carboxylic acid having formula 3. The process takes place by heating in organic solvent medium in the presence of sodium ethylate or alkali metal hydroxide. According to the second variant oxime having formula 2 interacts with acid halide or with anhydride of R′-carboxylic acid having formula 3. Thus is prepared intermediate compound having formula 4. It is isolated and/or dehydrated ( or its cyclization takes place ) by heating. EFFECT: improves efficiency of the method.