FIELD: organic chemistry. SUBSTANCE: o-cresol is used as reagent 1, sodium nitrite is used as reagent 2. Reaction is carried out in trifluoroacetic acid and glacial acetic acid medium in the presence of acetate of copper monohydrate, molar ratio o-cresol: sodium acetate : acetate of copper monohydrate: trifluoroacetic acid being 1: (1.5-2.5): (0.5-0.6): (4-10.7). The process takes place within 2-2.5 h at 5-10 C, sustaining time being 7-9 h, it is followed by oxidation thus prepared copper complex. Desired product possesses biological activity. EFFECT: improves efficiency of the method.
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Authors
Dates
1994-03-15—Published
1990-04-19—Filed