FIELD: medicine. SUBSTANCE: ethyl ester of 4-oxoheptane acid is used as reagent 1, amide of glycine is used as reagent 2. Reaction is carried out at 80-100 C and initial pressure of hydrogen 8-10 MPa in the medium of methanol. Said medium contains ammonia (1% ) and nickel boride (10% ). Desired product's melting point is 64-65 C. EFFECT: improves efficiency of the method.
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Authors
Dates
1994-03-15—Published
1991-05-12—Filed