FIELD: organic chemistry. SUBSTANCE: product: derivatives of benzocycloalkenyldihydrooxyalkanoic acid of the general formula I indicated in description of invention, where X - CH2 or O, or S; R1 and R2 - are identical or different and represent H, alkyl in C1-C3, or the form together the chain -(CH2)n- (n = 4 or 5) and, if necessary, they are substituted with one or two alkyl radical in C1-C3. R3 and R4 are identical or different: H, CF3, halogen (Cl, F, Br), N, N-dialkylamino in C1-C5, alkyl in C1-C4, alkoxy in C1-C5, alkylthio in C1-C3 or phenyl, which is substituted, if necessary, with two substitutes (not more). The latters may be identical or different and represent radicals alkyl in C1-C3, alkoxy in C1-C3, or halogens (F, Cl). When one of R3, R4 represents radicals: CF3, N, N-dialkylamino, C6H5 or substituted phenyl then it is occurs at positions 3′, 4′ or 5′ in the formula I, and other means hydrogen atom. R5 and R6 (which can be identical or different) represent H, halogen (F, Cl, Br), CF3, alkyl in C1-C3, alkoxy in C1-C3, C6H5, which, if necessary, is substituted with two substitutes (not more). The latters can be different or identical and represent radicals: alkyl in C1-C3, alkoxy in C1-C3, or halogen atoms (F, Cl) at condition: when one of R5, R6 represents CF3, C6H5 or substituted phenyl, then is occurred at position 6 or 7, and other one means hydrogen atom. Substitutes R3 and R4 and R5 and R6, respectively, can also form together (at condition of theirs location at two adjacent positions) biradicals of the following formulas: -CH= CH-CH= CH-, - (CH2)m-, -O(CH2)p-, where m = 3 or 4, p = 1 or 2. When R5 and R6 form chain O(CH2)pO, then it is bound with positions 3', 4' or 4', 5' and, respectively, with 6 and 7 in correspondence of the formula I. R7 and R8/ - H or they form together with bond C-C the double bond in trans-geometry; R9 and R10 - H or they form together dialkylmethylene group in C1-C3. Synthesized compounds are existed in the form of free acids, salts, esters, amides or δ-lactones. Reagent 1: ketoester of the general formula II indicated in description of invention, where X, R1R8 and R11 mean meanings indicated above. Reagent 2: complexing agent, for example, trialkylborane or dialkoxyalkylborane. Reaction conditions: low temperature following by treatment with alkaline metal boron hydride for 5-8 h and conversion of one the end product to another one. At the dose 0.23 mg/kg compounds I decrease cholesterol biosynthesis by 50 % that exceeds the preparation lovastatin (LD50 = 3200 mg/kg). Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis of compounds indicated above.
