METHOD OF SYNTHESIS OF 2-ANILINOPYRIMIDINE DERIVATIVES OR THEIR ACID- ADDITIVE SALTS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: products: derivatives of 2-anilinopyrimidine of the general formula (I) , where R₁ - H, halogen; R₂ - H, halogen, methyl; R₃ - (C₁-C₄) - alkyl unsubstituted or substituted with halogen, cyclopropyl; R₄ - cyclopropyl unsubstituted or substituted with halogen, methyl or their acid-additive salts. Urea is interacted with diketone of the general formula (II) R₃-C(O)CH₂C(O)R₄ in the presence of acid in inert solvent at 20-140 C following by cyclization at boiling point of phlegm with formation of 2-hydroxypyrimidine of the general formula (III) . Then hydroxy-group in compound prepared is replaced with haloid in the presence or absence of solvent by action of excess of compound PO(Hal)₃ at 50-110 C. Synthesized compound of the general formula (IV) is reacted with aniline derivative of the general formula (V) at 60-120 C in inert solvent in the presence or absence of acid. The end product is isolated in the free form or in the form of salt. Synthesized compounds are used in agriculture. EFFECT: improved method of synthesis. 4 tbl