FIELD: organic chemistry. SUBSTANCE: product: 4-bromoanilide of N-allyl-N- (adamantoyl-1') -anthranilic acid, empirical formula is C27H29BrN2O2, m. p. is 214-216 C, yield is 49%. Reagent 1: 4-bromoanilide of N-allylanthranilic acid. Reagent 2: adamantanecarboxylic acid chloroanhydride. Reaction conditions: in benzene medium, at 60-70 C. Synthesized compound is used in medicine. EFFECT: improved method of synthesis. 1 tbl
Title | Year | Author | Number |
---|---|---|---|
N-ALLYLANTHRANILIC ACID AMIDE ELICITING ANTI-INFLAMMATORY, ANALGETIC AND ANTIHYPOXIC ACTIVITY | 2000 |
|
RU2180656C1 |
N-(3'-CHLOROBUTENE-2'-YL)ANTHRANILIC ACID ACIARYLAMIDES ELICITING ANTI-INFLAMMATORY ACTIVITY | 2000 |
|
RU2181718C2 |
ANTI-INFLAMMATORY ACTIVITY | 1999 |
|
RU2170726C1 |
N-(3'-CHLOROBUTENE-2'-YL)-ANTHRANILIC ACID ANILIDE ELICITING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY | 2000 |
|
RU2180657C1 |
N-(3'-CHLOROBUTENE-2'-YL)-ANTHRANILIC ACID AMIDE SHOWING ANTI-INFLAMMATORY ACTIVITY | 2000 |
|
RU2189377C2 |
METHOD FOR SELECTION OF ANTI-INFLAMMATORY AGENTS | 2003 |
|
RU2242754C1 |
5-(N-METHYLPHENACYLIDENE)-2-IMINO-4-OXAZOLIDONE SHOWING ANTIINFLAMMATORY, ANALGETIC AND ANTIHYPOXIC ACTIVITIES | 1990 |
|
SU1690351A1 |
9-BENZYLIDENEHYDRAZINO-1,2,3,4-TETRAHYDROACRIDINE SHOWING ANALGETIC AND ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS | 1999 |
|
RU2161606C2 |
N-(5-BROMO-2-PYRIDYL)-AMIDE OF P-METHYLBENZOYLPYRUVIC ACID SHOWING ANTIINFLAMMATORY AND ANALGETIC ACTIVITY | 1991 |
|
RU2021262C1 |
Authors
Dates
1995-03-10—Published
1991-07-03—Filed