HYDROXYALKYLFURAN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: hydroxyalkylfuran derivatives of the formula (I) given in description text, - pharmaceutically acceptable salt of acid association of its or stereoisomeric compound where -A₁-A₂-A₃-A₄- - divalent radical with formula: -CH=CH-CH=CH- (a-1), -N=CH-CH=CH- (a-2), -CH=CH-CH=N- (a-5) or -N=CH-N=CH- (a-6), n=1 or 2B-NR₄ or CH₂; R₄ - H or C₁-C₆-alkyl; L - H, C₁-C₆-alkyl, C₁-C₆-alkylhydroxycarbonyl, or radical of the formula: -Alk-R₅ (b-1); -Alk-Y-R₆ (b-2), -Alk-Z₁-C(=X)-Z₂-R₇ (b-3), or -CH₂-CHOH-CH₂-O-R₈ (b-4) where R₅ - cyano-group, phenyl which does not obligatory substituted with alkoxy-C₁-C₆; pyridinyl; 4,5-dihydro-5- oxo-1H-tetrazolyl; 2-oxo-3-oxazolidinyl; 2,3-dihydro-2 -oxo-1H-benzimidazolyl; or bicyclic radical of the formula (c-4-a) where G₂ - -CH=CH-CH=CH-, -S-(CH₂)₃-, -S-(CH₂)₂-, -S-CH= CH- or -CH=C(CH₃)-O--group; R₆-C₁-C₆ - R₇-C₁-C₆-alkyl; pyridinyl which does not obligatory substituted with nitro-group; pyrimidinyl; pyrazinyl; pyridazinyl; 2,3-dihydro-3-oxopyridazinyl which does not obligatory substituted with halogen; or 9-methyl-6-purinyl; R₈-alkyl; haloidphenyl; Y - O or NH, Z₁ or Z₂ every independently is NH or direct bond, X - O, every Alk is independently C_1-6-alkanediyl. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 cl, 8 tbl