FIELD: pharmaceutical industry. SUBSTANCE: 2-[[(1-phenylmethyl)-4-piperidinyl] methyl]-1H-benzimidazole is used as reagent 1, 2-(chloromethyl)-6-methyl pyridine monohydrochloride being used as reagent 2. Reaction is carried out in solution of dimethylformamide in mineral oil in the presence of sodium hydride. The process takes place at room temperature. EFFECT: improves quality of desired product. 5 tbl
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE, OR THEIR SALTS, OR THEIR STEREOCHEMICALLY ISOMERIC FORM |
1990 |
- Zhorzh Anri Pol' Van Del'[Be]
- Frans Marija Al'Fons Van Den Kejbus[Be]
|
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| DERIVATIVES OF PYRAMIDINE-4-ONE OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND SEROTONIN-ANTAGONISTIC, DOPAMINE-ANTAGONISTIC AND ANTIGISTAMINE COMPOSITION ON THEIR BASES |
1990 |
- Lido Ehdmon Zhozefin Kennis[Be]
- Jan Vandenberk[Be]
- Jozef Martin Buj[Be]
|
RU2028297C1 |
| SUBSTITUTED ARYLOXYALKYLDIAMINES POSSESSING VASOCONSTRICTIV ACTIVITY |
1994 |
- Gi Rozali Ehzhen Van Lommen
- Marsel' Frans Leopol'D De Brjuin
- Pit Tom Bert Paul' Vigerink
|
RU2158126C2 |
| ETHERS OF (THIO)MORPHOLINYL- OR PIPERAZINYL ALKYLPHENOLS OR THEIR STEREOISOMERS, OR THEIR ACID-ADDITIVE SALTS AND ANTIVIRAL COMPOSITION |
1990 |
- Rajmon Antuan Stokbroks[Be]
- Marsel' Zhozef Marija Van Der Aa[Be]
|
RU2057130C1 |
| DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE AND PHARMACEUTICAL COMPOSITION |
1993 |
- Zhorzh Anri Pol' Van Del'[Be]
- Frans Marija Al'Fons Van Den Kejbus[Be]
|
RU2108332C1 |
| DERIVATIVES OF 1,2,3,4-TETRAHYDROBENZOFURO[3,2-C]-PYRIDINE, METHODS OF THEIR SYNTHESIS AND COMPOSITIONS BASED ON THEREOF |
1998 |
- Kennis Ljudo Ehdmond Zhozefin
- Lav Kristofer Dzhon
- Bishoff Fransua Pol'
|
RU2198175C2 |
| HYDROXYALKYLFURAN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1990 |
- Frans Ehduard Zhanssens[Be]
- Gaston Stanislas Marsella Dils[Be]
- Zhozef Ehlizaber Lenarts[Be]
|
RU2030415C1 |
| DERIVATIVES OF IMIDEAZOQUINAZOLINE SHOWING POSITIVE INOTROPIC AND LUSITROPIC PROPERTIES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT |
1990 |
- Ehddi Zhan Ehdgar Frejn[Be]
- Al'Fons German Margarita Rajmakers[Be]
|
RU2057753C1 |
| DERIVATIVES OF IMIDAZO[1,2A]THIENO[2,3-D]AZEPINES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1993 |
- Frans Ehduard Zhansen
- Gaston Stanislas Marsella D'El'
- Zhozef Ehlizabet Lenart
|
RU2134269C1 |
| 5,6-DIHYDRO-2-(SUBSTITUTED PHENYL)-1,2,4-TRIAZINE-3,5-(2H,4H)-DIONES SHOWING ANTICOXIDIAL AND COXIDIOSTATIC ACTIVITY |
1987 |
- Gustaf Marija Buks[Be]
- Al'Fons Kherman Margareta Raimakers[Be]
- Viktor Sipido[Be]
|
RU2017736C1 |
