FIELD: pharmaceutical industry. SUBSTANCE: product: 8-chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo-[4,3-a] [1,4] -benzodiazepine hydrate is prepared in the form of lamellar crystals of alprazolame from anhydrous compound as a result of water treatment or water-containing solvent. Preparing of this hydrate can be combined with purification step. EFFECT: improved method of synthesis. 8 cl
| Title | Year | Author | Number |
|---|---|---|---|
| CRYSTALLINE 8-CHLOR-1-METHYL-6-PHENYL-4H-1,2,4-TRIAZOLO(4,3-A)(1,4)-BENZODIAZEPINE HAVING PLATE FORM | 1992 |
|
RU2077536C1 |
| TRIAZOLO (4,3-a) 1,4 BENZO DIAZEPINES AND THRENO (3,2 | 1992 |
|
RU2094436C1 |
| METHOD OF SYNTHESIS OF TRIAZOLO-[4,3-A]-[1,4]-DIAZEPINES | 1988 |
|
RU2071962C1 |
| DERIVATIVES OF BENZODIAZEPINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2001 |
|
RU2278865C2 |
| SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRA-AZA-BENZO[E]AZULENES | 2009 |
|
RU2514429C2 |
| BICYCLIC LACTAMS AND METHODS OF USE THEREOF | 2016 |
|
RU2827714C1 |
| 0 |
|
SU444371A1 | |
| APPLICATION OF DIAZEPINES FOR PREPARING MEDICINAL AGENTS DESIGNATED FOR TREATMENT OF PATHOLOGICAL STATES OR DISEASES ASSOCIATED WITH EFFECT OF ONE AMONG SOMATOSTATIN RECEPTORS | 1999 |
|
RU2229299C2 |
| 0 |
|
SU324746A1 | |
| METHOD OF PREPARING IMIDAZO (2,5-A)-(1,4)-DIAZEPIN COMPOUNDS OR THEIR PHARMECETICALLY ADOPTED SALTS | 0 |
|
SU814278A3 |
