FIELD: pharmaceutical industry. SUBSTANCE: product: 8-chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo-[4,3-a] [1,4] -benzodiazepine hydrate is prepared in the form of lamellar crystals of alprazolame from anhydrous compound as a result of water treatment or water-containing solvent. Preparing of this hydrate can be combined with purification step. EFFECT: improved method of synthesis. 8 cl
| Title |
Year |
Author |
Number |
| CRYSTALLINE 8-CHLOR-1-METHYL-6-PHENYL-4H-1,2,4-TRIAZOLO(4,3-A)(1,4)-BENZODIAZEPINE HAVING PLATE FORM |
1992 |
- Fritts Bar[De]
- Karl Fridrikh Landgraf[De]
- Vol'Fgang Zauer[De]
- Sabine Gajsler[De]
- Eberkhard Shubert[De]
|
RU2077536C1 |
| TRIAZOLO (4,3-a) 1,4 BENZO DIAZEPINES AND THRENO (3,2 |
1992 |
|
RU2094436C1 |
| METHOD OF SYNTHESIS OF TRIAZOLO-[4,3-A]-[1,4]-DIAZEPINES |
1988 |
|
RU2071962C1 |
| DERIVATIVES OF BENZODIAZEPINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2001 |
- Raffaehllo Maschiadri
- Ehndr'Ju Uill'Jam Tomas
- Jurgen Vikhmann
|
RU2278865C2 |
| SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRA-AZA-BENZO[E]AZULENES |
2009 |
- Bissants Katerina
- Getshi Ehrvin
- Jakob-Roehtne Roland
- Maskiadri Rafaehllo
- Pinar Ehmmanjuehl'
- Ratni Khasan
- Rodzhers-Ehvans Mark
- Shnajder Patrik
|
RU2514429C2 |
|
0 |
|
SU444371A1 |
| APPLICATION OF DIAZEPINES FOR PREPARING MEDICINAL AGENTS DESIGNATED FOR TREATMENT OF PATHOLOGICAL STATES OR DISEASES ASSOCIATED WITH EFFECT OF ONE AMONG SOMATOSTATIN RECEPTORS |
1999 |
- Bigg Denni
- Liberator Ann-Mari
- Pomm'E Zhak
- Tejlor Dzhon
|
RU2229299C2 |
|
0 |
|
SU324746A1 |
| CRYSTALLINE SOLID FORM OF A BENZENE SULPHONIC ACID SALT AND 2-[(4S)-6-(4-CHLOROPHENYL)-1-METHYL-8-(METHYLOXY)-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]-N-ETHYLACETAMIDE, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
2015 |
- Campbell Gossett Augustus
- Gladwin Asa Elisabeth
|
RU2697393C2 |
| METHOD OF PREPARING IMIDAZO (2,5-A)-(1,4)-DIAZEPIN COMPOUNDS OR THEIR PHARMECETICALLY ADOPTED SALTS |
0 |
- Rodnij Aen Frajer
- Armin Valzer
|
SU814278A3 |
