FIELD: organic chemistry. SUBSTANCE: product: derivative of imidazole of the formula (I) 
where R1 and R2, which can be similar or different each H, CH3, C2H5, OCH3 or halogen; R′ H or radical of the formula (II) 
where R3 H; R4 H and R5 H or OH, or R4 and R5 together form the bond and X bond or C1-C2-alkyl with normal chain. Product is synthesized by interaction of 4(5)-imidazolepropionic acid alkyl ester of the formula (III) 
where R′ as indicated above, and R is alkyl with Grignard reagent of the formula (IV) 
where R1 and R2 as indicated above, and Hal halogen followed by if necessary product dehydration and hydrogenation (nonobligatory) and interaction with strong base and then with benzyl halogenide of the formula R3-C6H4-CH2Hal and hydrogenation. Prepared compound is conversed to acid-additive nontoxic pharmacologically accepatable salt used in new pharmaceutical compositions. EFFECT: improved method of synthesis.
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLES OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS | 0 |
|
SU1819263A3 |
| METHOD OF OBTAINING 2,4-DIAMINO-5-(SUBSTITUTED) PYRAMIDINES | 0 |
|
SU1819264A3 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 1990 |
|
RU2021263C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLES OR THEIR PHARMACEUTICAL ACCEPTABLE ACID ADDITIVE SALTS | 1991 |
|
RU2067578C1 |
| METHOD FOR OBTAINING SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 0 |
|
SU1836355A3 |
| SUBSTITUTED 4(5)-IMIDAZOLES OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS WITH ACIDS | 1991 |
|
RU2036193C1 |
| METHOD OF PRODUCING IMIDAZOLE DERIVATIVES OR THEIR SALTS | 0 |
|
SU1074404A3 |
| PROCESS FOR PREPARING DERIVATIVES OF IMIDAZOLE OR THEIR HYDROCHLORIDES | 0 |
|
SU997607A3 |
| METHOD OF PRODUCING IMIDAZOLE SUBSTITUTED DERIVATIVES | 0 |
|
SU1241990A3 |
| METHOD FOR OBTAINING SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 0 |
|
SU1836354A3 |
