FIELD: organic chemistry. SUBSTANCE: product: 6-oxa-8-isoanalog of steroid estrogens of the formula (I) where R1=CH3, C2H5, C3H7; R2 - H, CH3; R3 - H, CH3; R4, R5 =O, 
; n = 0. Reagent 1: 6-oxa-1,3,5(10),8,14-estrapentene. Reagent 2: hydrogen over Raney nickel. Reaction conditions: in benzene at 80-110 C, under pressure 10-15 MPa, the yield is 48.69%. Structure of compound of the formula I:
EFFECT: improved method of synthesis.
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| RACEMIC 3,17β-DIHYDROXY-7α,18-DIMETHYL-6-OXAEXTRA-1,3,5( 10 ),8(9)-TETRAENE DIACETATE EXHIBITING OSTEOPROTECTIVE, HYPOCHOLESTEREMIC AND ANTIOXIDANT ACTION | 2009 |
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| RACEMIC 3-HYDROXY-16-METHYL-2-FLUORO-13a-ESTRA-1,3,5(10),8(9),15-PENTAEN-17-ONE AS MEANS OF HORMONE REPLACEMENT THERAPY AND METHOD OF OBTAINING THEREOF | 2013 |
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