RACEMIC 3-HYDROXY-16-METHYL-2-FLUORO-13a-ESTRA-1,3,5(10),8(9),15-PENTAEN-17-ONE AS MEANS OF HORMONE REPLACEMENT THERAPY AND METHOD OF OBTAINING THEREOF Russian patent published in 2014 - IPC C07J15/00 C07J75/00 A61K31/566 

Abstract RU 2526264 C1

FIELD: chemistry.

SUBSTANCE: invention relates to racemic 3-hydroxy-16-methyl-2-fluoro-13α-estra-1,3,5(10),8,15-pentaen-17one of formula , which is used as an inducer of high-density lipoproteids, as well as to a method of its obtaining. The method includes reaction of 6-hydroxy-7-fluorotetralone-1 with vinylmagnesium bromide, condensation of formed vinylcarbinol with 2,4-dimethylcyclopentan-1,3-dion with further cyclohydration of the obtained secocompound under action of p-toluenesulfonic acid in toluene.

EFFECT: improved properties of compounds.

2 cl, 1 ex

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RU 2 526 264 C1

Authors

Shavva Aleksandr Grigor'Evich

Morozkina Svetlana Nikolaevna

Fidarov Alan Fidarovich

Eshchenko Natal'Ja Dmitrievna

Dates

2014-08-20Published

2013-02-05Filed