FIELD: chemistry.
SUBSTANCE: invention relates to racemic 3-hydroxy-16-methyl-2-fluoro-13α-estra-1,3,5(10),8,15-pentaen-17one of formula , which is used as an inducer of high-density lipoproteids, as well as to a method of its obtaining. The method includes reaction of 6-hydroxy-7-fluorotetralone-1 with vinylmagnesium bromide, condensation of formed vinylcarbinol with 2,4-dimethylcyclopentan-1,3-dion with further cyclohydration of the obtained secocompound under action of p-toluenesulfonic acid in toluene.
EFFECT: improved properties of compounds.
2 cl, 1 ex
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Authors
Dates
2014-08-20—Published
2013-02-05—Filed