FIELD: organic chemistry, pharmaceutical industry. SUBSTANCE: product: new derivatives of 4-(2-pyrimidinyl)-1-piperazinyl of the formula (I) $$$ where: R - hydrogen atom; n = 1-6; Het is taken from imidazole or pyrazole of the formula (II) $$$ where A and B are different and mean carbon or nitrogen atom; R and R - are similar or different and mean hydrogen, halogen, lower alkyl, nitro, cyano, phenyl or phenyl substituted with halogen; or R and R or R and R form together alkylene chain containing four carbon atoms that can be saturated or unsaturated, or pharmaceutically acceptable salts. Synthesized compounds show biological activity, in part, anxiolytic one. EFFECT: improved method of synthesis, enhanced effectiveness. 5 tbl
