4-[2-(2-HYDROXY-2-PHENYLETHYLAMINO)ETHOXY]-PHENYLACETIC ACID OR ITS BIOPRECURSOR OR PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF ITS SYNTHESIS, COMPOSITION BASED ON THEREOF Russian patent published in 1997 - IPC

Abstract RU 2073666 C1

FIELD: organic chemistry. SUBSTANCE: product: 4-[2-(2-hydroxy-2-phenylethylamino)ethoxy]-phenylacetic acid of the formula 4-C6H5CH(OH)CH2NHCH2CH2OC6H4CH2COOH or its bioprecursor taken from amide or ester, or pharmaceutically acceptable salt and pharmaceutical composition. Reagent 1: styrene oxide. Reagent 2: 4-(H2NCH2CH2O)C6H4CH2COR4, COR4-amide group. Reaction conditions: at heating and at the following if necessary product hydrolysis to prepare acid and conversion of the latter if necessary to ester and product isolation if necessary as pharmaceutically acceptable salt. Synthesized compounds were used as bioactive substances and can be used in medicine. EFFECT: improved method of synthesis. 12 cl, 4 tbl

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RU 2 073 666 C1

Authors

Brajan Roj Khollouehj[Gb]

Ral'F Khouv[Gb]

Val'Bir Singkh Rao[Gb]

Dates

1997-02-20Published

1992-05-20Filed