FIELD: organic synthesis and biologically-active compounds. SUBSTANCE: invention provides quinazoline derivatives of formula I: 
(I) where n=2, each of R2 are independently halogen atoms, R3 is C1-C4-alkoxy, and R1 is di(C1-C4-alkyl)amino-C2-C4-alkoxy, pyrrolydin-1-yl-C2-C4-alkoxy, piperidine-C2-C4-alkoxy, morpholine-C2-C4-alkoxy, piperazine-1-yl-C2-C4- alkoxy, 4-C1-C4-alkylpiperazin-1-yl-C2-C4-alkoxy, imidazol-1-yl-C2-C4-alkoxy, or di(C1-C4-alkoxy-C2-C4-alkyl)amino-C2-C4-alkoxy, and where one of above- indicated substituents R1 containing methylene group not linked to nitrogen and oxygen atoms optionally contains hydroxyl substituents in said methylene group, and pharmaceutically acceptable salts of compounds I. Inhibitory activity of above-listed compounds is utilized to suppress receptor tyrosinekinases in treatment of proliferative diseases such as cancers. EFFECT: extended choice of antiproliferative preparations. 20 cl, 3 tbl, 32 ex
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Year |
Author |
Number |
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1993 |
|
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1997 |
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1997 |
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- Klehjton Ehdvard
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1996 |
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2000 |
- Ehnneken Loran Fransua Andre
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|
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1996 |
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|
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1993 |
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1994 |
- Majkl Taddeus Klimas
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| DERIVATIVES OF PYRIDAZINOQUINOLINE |
1994 |
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