FIELD: organic chemistry. SUBSTANCE: product: 13,14-dihydro-17-phenyl-analogs of PGF2α or PGF2 synthesized by double bond hydrogenation in an intermediate compound (I) PGF2α without allyl alcohol deoxygenation and one of an intermediate compound (II) PGF2 or (III) 
is obtained. In these compounds R - hydrogen or one or more halogens, hydroxyl, cyanide, alkyl (preferable containing 1-4 carbon atoms), hydroxyalkyl, trifluoromethyl or aromatic or heteroaromatic substituents in aromatic ring; 
and 
- each is hydrogen, alkyl (preferably containing 1-4 carbon atoms), hydroxyl, haloid or hydroxyalkyl-substituents; R1 - O-alkyl or N-(alkyl); P - protective group. Synthesized compounds were used in ophthalmology as drugs that decrease eye pressure. EFFECT: improved method of synthesis, enhanced effectiveness. 4 cl, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF 13,14-DIHYDRO-15(R)-17-PHENYL-18,19,20-TRINOR-PGF2α ESTER | 1993 |
|
RU2099325C1 |
| DERIVATIVES OF 2,3,4-TRINOR-1,5-INTER-M-PHENYLENPROSTACYCLINE HAVING CYTOPROTECTIVE PROPERTIES | 0 |
|
SU1382834A1 |
| DERIVATIVES OF PROSTAGLANDINS WITHOUT ADVERSE EFFECTS FOR GLAUCOMA TREATMENT | 1998 |
|
RU2207858C2 |
| PROCESS FOR PREPARING DERIVATIVES OF 16-AMINO-18,19,20-TRINOR-PROSTAGLANDINE OR THEIR ACID ADDITION SALTS | 0 |
|
SU1093244A3 |
| APPLICATION OF α-METHYL-P-TYROSINE FOR INHIBITION OF PRODUCING IRIS MELANIN | 1998 |
|
RU2218159C2 |
| METHOD OF PRODUCING DERIVATIVE OF INTER-M-PHENYLENE-PROSTACYCLINES | 0 |
|
SU1391501A3 |
| METHOD OF OBTAINING DERIVATIVES OF 2,3,4-TRINOR-M-INTER-PHENYLPROSTAGLANDINE | 0 |
|
SU1138020A3 |
| METHOD OF PREPARING OPTICALLY ACTIVE FLUOROPROSTAGLANDINES OR THEIR RACEMATES | 0 |
|
SU710516A3 |
| METHOD OF PRODUCING BICYCLIC PROSTAGLANDINES AND SALTS THEREOF | 0 |
|
SU978725A3 |
| METHOD OF PRODUCING 9-DIOXI-9A-METHYLENE ISOSTERS OR THEIR LACTONES | 0 |
|
SU1360582A3 |
