FIELD: organic chemistry. SUBSTANCE: product: 13,14-dihydro-15(R)-17-phenyl-18,19,20-trinor-PGF2α esters of the formula (I) given in description. Compounds were synthesized by reduction of chain-side oxo-group of the corresponding lactone of the formula (VII), hydration of the obtained compound (VI) to 3,3a,4,5,6,6a-hexahydro-2-oxo-4-[51-phenyl-31-(R)-hydroxy- -11-pentyl] -5-(41-phenylbenzoylhydroxy)-2H-cyclopenta-[b] - -furan of the formula (V); then 2-oxogroup of the compound (V) is reduced to (IV) and the end product (I) is obtained after stages of protecting group removal, cycle cleavage and alkylation. The synthesized compounds were used as drugs of broad action spectrum. EFFECT: improved method of synthesis. 10 cl
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Authors
Dates
1997-12-20—Published
1993-02-23—Filed