METHOD OF SYNTHESIS OF 13,14-DIHYDRO-15(R)-17-PHENYL-18,19,20-TRINOR-PGF2α ESTER Russian patent published in 1997 - IPC

Abstract RU 2099325 C1

FIELD: organic chemistry. SUBSTANCE: product: 13,14-dihydro-15(R)-17-phenyl-18,19,20-trinor-PGF2α esters of the formula (I) given in description. Compounds were synthesized by reduction of chain-side oxo-group of the corresponding lactone of the formula (VII), hydration of the obtained compound (VI) to 3,3a,4,5,6,6a-hexahydro-2-oxo-4-[51-phenyl-31-(R)-hydroxy- -11-pentyl] -5-(41-phenylbenzoylhydroxy)-2H-cyclopenta-[b] - -furan of the formula (V); then 2-oxogroup of the compound (V) is reduced to (IV) and the end product (I) is obtained after stages of protecting group removal, cycle cleavage and alkylation. The synthesized compounds were used as drugs of broad action spectrum. EFFECT: improved method of synthesis. 10 cl

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RU 2 099 325 C1

Authors

Jozhef Ivanich[Hu]

Tibor Sabo[Hu]

Ishtvan Khermets[Hu]

Djula Dalmadi[Hu]

Jozhefnej Ivanich[Hu]

Gabornej Kovach[Hu]

Resjul Bakhram[Se]

Dates

1997-12-20Published

1993-02-23Filed