FIELD: medicinal biochemistry, endocrinology. SUBSTANCE: product: decapeptide fragment of the formula: HOOC-Asn-Cys- -S-S-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-COOH showing biological activity of insulin. Reagent 1: dipeptide: Cys-Asn. Reagent 2: octapeptide: Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr. Reaction conditions: synthesis is carried out in peptide synthesizer by dicyclocarbodiimide method in the presence of 1-hydroxybenzotriazole and using 9-fluorenylmethoxycarbonyl-(Fmoc)-protected amino acids. Yield is 20%. EFFECT: improved method of synthesis, increased yield. 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| INSULIN ANALOGUES | 2017 |
|
RU2769476C2 |
| HALOGEN-STABILISED INSULIN | 2009 |
|
RU2555557C2 |
| HYBRID PROTEIN CONTAINING FRAGMENTS OF FLUORESCENT PROTEINS AND ITS APPLICATION | 2020 |
|
RU2801248C2 |
| METHODS FOR TREATMENT OF SEVERE INSULIN RESISTANCE BY INTERRUPTING GLUCAGON RECEPTOR SIGNAL TRANSMISSION | 2017 |
|
RU2772508C2 |
| PEPTIDES OF COUNTERINSULAR ACTION | 1998 |
|
RU2182491C2 |
| COMPOSITIONS AND METHODS FOR CONTROLLING ACCUMULATION OF ADIPOSE TISSUE | 2014 |
|
RU2711478C2 |
| COMPOUND CONTAINING THERAPEUTIC ENZYME AND TRANSPORT ELEMENT CONNECTED TO EACH OTHER DIRECTLY OR BY USING LINKER | 2022 |
|
RU2811100C1 |
| INSULIN-INCRETIN CONJUGATES | 2014 |
|
RU2678134C2 |
| INSULIN ANALOGUES WITH REDUCED AFFINITY TO INSULIN RECEPTOR AND THEIR USE | 2017 |
|
RU2764197C1 |
| INSULIN ANALOGUE COMPLEX WITH REDUCED AFFINITY TO INSULIN RECEPTOR AND ITS USE | 2018 |
|
RU2779462C2 |
