FIELD: medicinal biochemistry, endocrinology. SUBSTANCE: product: decapeptide fragment of the formula: HOOC-Asn-Cys- -S-S-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-COOH showing biological activity of insulin. Reagent 1: dipeptide: Cys-Asn. Reagent 2: octapeptide: Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr. Reaction conditions: synthesis is carried out in peptide synthesizer by dicyclocarbodiimide method in the presence of 1-hydroxybenzotriazole and using 9-fluorenylmethoxycarbonyl-(Fmoc)-protected amino acids. Yield is 20%. EFFECT: improved method of synthesis, increased yield. 3 dwg
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