1,7-ANULAR DERIVATIVES OF 3-(PIPERAZINOALKYL)-INDOLE, METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND AN INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS Russian patent published in 1997 - IPC

Abstract RU 2083580 C1

FIELD: organic chemistry. SUBSTANCE: product: 1,7-anular derivatives of 3-(piperazinoalkyl)-indole of the formula (I) where: R1 means hydrogen, lower alkoxyl, lower thioalkyl, hydroxyl, halogen, nitro and other groups; R2 means hydrogen, halogen, lower alkyl and others; R3 means hydrogen, lower alkyl and others; R4 means hydrogen, C1-C7-alkyl, C3-C7-alkenyl, C3-C6-cycloalkyl and others; A means sulfur, oxygen, alkylene chain with 2-4 carbon atoms; R means nitrogen or CH-group; R5 means pyridinyl, phenyl substituted if necessary with lower alkyl, alkoxyl, halogen; D means the bond and also an intermediate compound of the formula (IV) where A means CH2-; B means -CH2-; R5 means lower alkyl; means hydrogen, lower alkyl, nitro-group; R6 means lower alkylcarbonyl; R2 means hydrogen, lower alkyl; R7 means hydrogen, C1-C7-alkyl; Q means Q′-CO-chain where Q′ means alkylene chain with 1-3 carbon atoms. Compounds of the formula (I) were synthesized by interaction of compound of the formula (II) with compound of the formula (III) or by reduction of compound of the formula (IV) or (I) where RIV1

- hydrogen, amino-group followed by acylation with acids or their reactive derivatives. Synthesized compounds were used in medicine as drugs. EFFECT: improved method of synthesis. 13 cl, 6 tbl

Similar patents RU2083580C1

Title Year Author Number
METHOD OF PRODUCING 2-ACYLAMINOMETHYL-1H-2,-3-DIHYDRO-1,4-BENZODIAZEPINES OR ACID-CONNECTING SALTS THEREOF 0
  • Khorst Tsojgner
  • Ditmar Remer
  • Khans Lipmann
  • Volfgang Milkovski
SU1253430A3
METHOD OF PRODUCTION OF (1.2)-ANILINATED 1.4-BENZODIAZOPINES OR THEIR OPTICAL ISOMERS OR ACID-ADDITIVE SALTS 0
  • Khans Lipmann
  • Mikael Ruland
  • Kherbert Myush
  • Verner Benzon
  • Khennig Khajnemann
  • Khorst Tsojgner
SU1331431A3
METHOD OF PRODUCING 2-ACYLAMINOMETHYL-1H-2,3-DIHYDRO-1,4-BENZODIAZEPINE COMPOUNDS,AS WELL AS THEIR OPTICAL ISOMERS AND THEIR ACID-COMBINATION SALTS 0
  • Khorst Tsojgner
  • Ditmar Remer
  • Verner Benzon
  • Khans Lipmann
  • Volfgang Milkovski
SU1245259A3
METHOD OF PRODUCING 1-PHENYL-2-AMINOCARBONYLINDOLE COMPOUNDS OR THEIR SALTS OF ACID CONNECTION 0
  • Khajnrikh-Vilkhelm Olendorf
  • Vilkhelm Kaupmann
  • Ulrikh Kyul
  • Gerd Bushmann
  • Shtefen Dzhon Magda
SU1195903A3
6-OXO-AZEPINOINDOLE COMPOUNDS AND THEIR PHYSIOLOGICALLY TOLERANTABLE ACID SALTS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF THEIR SYNTHESIS 1992
  • Verner Benzon[De]
  • Karin Van Kharldorp[Nl]
  • Piter Kolin Gregori[Gb]
  • Klaus-Ull'Rikh Vol'F[De]
  • Ul'F Projshoff[De]
  • Martin Tjulp[Nl]
  • Ton Khjulkenberg[Nl]
  • Ineke Van Vejngarden[Nl]
RU2078765C1
PROCESS FOR PREPARING DERIVATIVES OF 3-AMINO-1-BENZOXEPINE OR THEIR STEREOISOMERS OR THEIR SALTS 0
  • Khajnrikh-Vilkhelm Olendorf
  • Klaus-Ulrikh Volf
  • Vilkhelm Kaupmann
  • Khenning Khajnemann
SU1017170A3
TRICYCLIC NITROGEN-CONTAINING COMPOUNDS AND TETRAHYDROQUINOLINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS 1991
  • Mal'Kol'M Vilson Mun[Us]
  • Richard Frederik Khejer[Us]
  • Dzhenett Kej Morris[Us]
RU2023712C1
PROCESS FOR PRODUCING NB-QUATERNARY DERIVATIVES OF 10-BROMOISOAJMALINE 0
  • Volfgang Kerbakh
  • Joakhim Vegener
  • Ulrikh Kyul
  • Renke Budden
  • Gerd Bushmann
SU963470A3
METHOD OF OBTAINING DERIVATIVES OF N-AMINOALKYLINDOLE OR SALTS THEREOF 0
  • Khenning Khajnemann
  • Khajnrikh Vilkhelm Olendorf
  • Klaus-Ulrikh Volf
SU1119606A3
METHOD OF PRODUCING 1-PHENYL-2-AMINOCARBONYLINDOLE COMPOUNDS OR ACID-ADDITIVE SALTS THEREOF 0
  • Khajnrikh-Vilkhelm Olendorf
  • Vilkhelm Kaupmann
  • Ulrikh Kyul
  • Gerd Bushmann
  • Shtefen Dzhon Magda
SU1223843A3

RU 2 083 580 C1

Authors

Daniehl' Zhasseran[Us]

Dominik Pari[Us]

Patris Demonsho[Us]

Mishel' Kottin[Us]

Fransua Flosh[Us]

P'Er Djupass'E[Fr]

Richard Vajt[Us]

Dates

1997-07-10Published

1992-08-21Filed