FIELD: organic chemistry. SUBSTANCE: product: 1,7-anular derivatives of 3-(piperazinoalkyl)-indole of the formula (I) where: R1 means hydrogen, lower alkoxyl, lower thioalkyl, hydroxyl, halogen, nitro and other groups; R2 means hydrogen, halogen, lower alkyl and others; R3 means hydrogen, lower alkyl and others; R4 means hydrogen, C1-C7-alkyl, C3-C7-alkenyl, C3-C6-cycloalkyl and others; A means sulfur, oxygen, alkylene chain with 2-4 carbon atoms; R means nitrogen or CH-group; R5 means pyridinyl, phenyl substituted if necessary with lower alkyl, alkoxyl, halogen; D means the bond and also an intermediate compound of the formula (IV) where A means CH2-; B means -CH2-; R5 means lower alkyl; means hydrogen, lower alkyl, nitro-group; R6 means lower alkylcarbonyl; R2 means hydrogen, lower alkyl; R7 means hydrogen, C1-C7-alkyl; Q means Q′-CO-chain where Q′ means alkylene chain with 1-3 carbon atoms. Compounds of the formula (I) were synthesized by interaction of compound of the formula (II) with compound of the formula (III) or by reduction of compound of the formula (IV) or (I) where R
Authors
Dates
1997-07-10—Published
1992-08-21—Filed