DERIVATIVES OF HYDRAZINE OR THEIR SALTS, PHARMACEUTICAL AGENT, AMINOALKYLHYDRAZINES OR THEIR SALTS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of hydrazine of the general formula (I): R₁R₂N-C(R₃R₄)-C(R₅R₆)-N-(R₇)-N-(R₈R₉) (I) where: R₁ and R₉ mean independently - hydrogen, lower alkanoyl, phenyl-(lower)-alkanoyl, phenyl-(lower)-alkanoyl where residue of lower alkanoyl is substituted with carbamoyl, morpholino-(lower)-alkanoyl, thiomorpholino-(lower)-alkanoyl, pyridyl-(lower)-alkanoyl, quinolyl-(lower)-alkanoyl, tetrazolyl-(lower)-alkanoyl, amino-(lower)-alkanoyl substituted at amine nitrogen with N-morpholino- or N-thiomorpholinocarbonyl, halogen-(lower)-alkanoyl containing up to three halogen atoms, 2-(morpholino-(lower)-alkylcarbamoyl)-lower alkanoyl, 2-(N-pyridyl-(lower)-alkylcarbamoyl)-lower alkanoyl, lower alkoxycarbonyl, phenyl-(lower)-alkoxycarbonyl, tetrahydrofuranyl-(lower)-alkylhydroxycarbonyl, lower alkylsulfonyl, N-pyridyl-(lower)-alkyl-N-(lower)-alkylcarbamoyl, or amino acid acyl residue taken from: glycine, alanine, valine, leucine, isoleucine, glutamic acid and asparagine in the form of (D)-, (L)- or (D,L)-isomers where α-amino group is free or acylated with one of above indicated residue R₁ or R₉ at condition that at least one of residue R₁ and R₉ means hydrogen; R₂, R₄, R₆ and R₈ mean hydrogen; R₃ - lower alkyl, cyclohexyl-(lower)-alkyl or phenyl-(lower)-alkyl that can be free or substituted with halogen lower alkoxy or cyano-groups; R₅ means hydroxyl group; R₇ - lower alkyl, cyclohexyl-(lower)-alkyl or phenyl-(lower)-alkyl that can be free or substituted with halogen, lower alkoxy or cyano-groups, or their salts. Pharmaceutical agent has an effective dose of compounds of the formula (I) and hydrazine derivative of the formula (II) H₂N-HC(R₃)-CH-(OH)-N-(R₇)NH₂ (II) - intermediate compounds for synthesis of (I). Synthesized compounds inhibit activity of enzyme protease and show antiviral activity. EFFECT: improved method of synthesis. 10 cl