FIELD: biotechnology, genetic engineering. SUBSTANCE: dipeptidylaminopeptidase is isolated from cellular mucosal fungus Dictyostelium discoideum ATCC 28368, its molecular mass is about 225000 Da and able to split off aminoterminal dipeptide Met-Tyr, Met-Arg or Met-Asp from the corresponding polypeptide sequence. Enzymatic splitting off the indicated dipeptide is carried out at pH = 2.5-5.5, at 15-45 C for 1 min - 24 h depending on the nature of the substrate used. EFFECT: improved method of splitting off. 6 cl
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