METHOD OF MINIMIZATION OF DEGRADATION OF ACTIVATED PROTEIN C (VERSIONS), STABILIZED COMPOSITION OF ACTIVATED PROTEIN C Russian patent published in 2001 - IPC

Abstract RU 2167936 C2

FIELD: biotechnology, proteins. SUBSTANCE: method involves incubation of activated protein C in salt solution at low pH values, from about 6.3 to about 6.5. Autodegradation of activated protein C can be minimized by incubation of activated protein C in 3 M urea also. Complete isolation of activity of activated protein C can be obtained after removal of denaturating agent or by incubation of activated protein C in the presence of extreme salt concentrations. Invention relates to stabilized composition of activated protein C that supports activated protein C at low pH values, in denaturating agent or at extreme salt concentrations. Invention provides minimal autodegradation of activated protein C. EFFECT: improved method of minimal degradation. 17 cl, 4 tbl, 4 ex

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RU 2 167 936 C2

Authors

Val'Ter Frehnsis Prauti, Ml.

Dzhozefin Seknik

Dates

2001-05-27—Published

1995-01-04—Filed