FIELD: medicine; chemistry of biologically active compounds. SUBSTANCE: derivatives of pyrazine having formula I given in specification are prepared by interaction of sodium salt of pyrazine-2-carboxamide with 6-methyl-5-uracil sulfochloride which takes place in liquid ammonia. Sodium salt of pyrazine-2-carboxamide is preliminary prepared by interaction of pyrazine amide with sodium amide which is carried out in the medium of liquid ammonia. LD50 of compound is 2350-8000 mg/kg, it has high immunostimulating action within wide range of doses. EFFECT: improved quality, improved efficiency. 3 cl, 3 tbl
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RU2074856C1 |
| ISONICOTINIC ACID HYDRAZIDE OROTATE HAVING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITIES | 1990 |
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|
RU2136668C1 |
| N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULFONE)-N′- ISONICOTINOYL HYDRAZIDE DISODIUM SALT ELICITING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITY AND MEDICINAL AGENT BASED ON THEREOF | 1999 |
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RU2191015C2 |
| 6-ALKYL-5-(2-ISONICOTINOYLSULFOHYDRAZOYL)URACIL HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2003 |
|
RU2264396C2 |
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RU2275356C2 |
| IMMUNOTROPIC N, N '-(SULPHONYLDI-1,4-PHENYLENE)BIS[(N",N'"-DIMETHYL)METHYLIMINOMETHANE]1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINESULPHONATE | 2007 |
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RU2357960C1 |
| NOVEL MEDICINAL FORMS OF DIMOCIFON IN LEPROSY THERAPY, ITCHING AND ALLERGODERMATOSIS, DURING'S DERMATITIS HERPETIFORMIS | 1999 |
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RU2200550C2 |
| METHOD OF OBTAINING EXTRACT POSSESSING ANTI-LEPROSY ACTIVITY | 2009 |
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| SALT OF BIS(OXYMETHYL)PHOSPHINIC ACID WITH ISONICOTINIC ACID HYSRAZIDE (TUBOPHEN) HAVING ANTITUBERCULOSIS ACTION AND METHOD FOR PRODUCTION THEREOF | 2005 |
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RU2281939C1 |
