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2 108 331

(13)

(51)

IPC

(21) (22)

Application

95116238/04, 1995-09-18

(22)

Actual filing date

1995-09-18

(45)

Published

1998-04-10

(72)

Inventor

Ehlizabet Smit Labell'[Us]Vejn Duglas Ljuk[Us]Dzhon Maknejll Makdzhill Iii[Us]Rendal Skot Miller[Us]

(73)

Holder

Ehli Lilli Ehnd Kompani

METHOD OF SYNTHESIS OF CRYSTALLINE SOLVATE, CRYSTALLINE SOLVATE OF 6-HYDROXY-2-(4-HYDROXYPHENYL)-3-[4-(2-PIPERIDINEETH- -OXY)BENZOYL]BENZO[B]THIOPHENE HYDROCHLORIDE Russian patent published in 1998 - IPC

Abstract RU 2108331 C1

FIELD: organic chemistry. SUBSTANCE: invention relates to method of synthesis of crystalline solvate or nonsolvated crystalline 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidineethoxy)benzoyl- -benzo[b] thiophene hydrochloride by acylation of protected derivative of 2-arylbenzothiophene in the presence of boron trichloride or tribromide followed by isolation of crystalline solvate, its dissolving in hot solution containing methanol and water and solution concentrating. EFFECT: improved method of synthesis. 11 cl, 6 tbl

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RU 2 108 331 C1

Authors

Ehlizabet Smit Labell'[Us]

Vejn Duglas Ljuk[Us]

Dzhon Maknejll Makdzhill Iii[Us]

Rendal Skot Miller[Us]

Dates

1998-04-10—Published

1995-09-18—Filed