PEPTIDES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1998 - IPC

FIELD: chemistry of peptides, medicine. SUBSTANCE: peptides containing from 8 to 15 amino acid residues of the general formula (I): Xaa-Zaa-$$$-Xaa-Yaa-Pro-Ala-Asp-Zaa-Ala-$$$ where molecule can be fused to cycle by amide bond between the first and the last amino acid residue; Xaa = Ala, $$$-Ala, Leu, Ile, Gly, Val, Nle, Nva; Yaa = Arg, Lys, Orn, His; Zaa = Aad, Apm, Asp, Glu and at least one of residues Xaa or Zaa is absent. Pharmaceutical composition has one or some peptides of the formula (I) taken at effective amount in mixture with pharmaceutically solid or liquid carrier and can be used for prophylaxis of gastroenteric ulcer formation, radiation injure and malformation, protection at chemical burn, edema, trauma, bone fracture, viral infection, depressive and shock states, disorders of dopamine-ergic etiology. Peptides show organ-protective activity and can be used in medicine. EFFECT: enhanced effectiveness of peptides. 14 cl, 7 dwg