HOLICHONDRIN B DERIVATIVES, CONDENSED PYRAN DERIVATIVES (VARIANTS), HYDROGENATED FURAN DERIVATIVES, HYDROGENATED PYRAN DERIVATIVES, GALICHONDRIN B ENONE DERIVATIVES AND NORGALICHONDRIN ENONE DERIVATIVES Russian patent published in 1998 - IPC

FIELD: medicine, particularly, manufacture of antitumor drugs. SUBSTANCE: antitumor drugs have structural formula I wherein R₁ and R₂ are C_1-6-alkyl; A is unprotected of protected group of formula: CH₂CH₂OH; B is unprotected or protected OH; m=n=1. Intermediate compounds have structural formula II wherein R₁ is C_1-6-alkyl; R₂ is protected OH, R₃ is CHO, CO₂D wherein D is C_1-5-alkyl; R₄ is unprotected or protected OH; R₅ is protected or unprotected OH or protected CH₂CH₂OH; structural formula III wherein X is OH, R₁,R₂,R₃ are protected OH; R₄ is CO₂D in which D is C₁-C₅-alkyl; structural formula IV wherein R₁-R₅ is protected OH, R₆ is oxygen, R₇-R₈ is C_1-5 alkyl; X is halogen; structural formula V wherein R₁-R₆ is protected OH, R₄ is oxygen, R₅-R₆ is C_1-5- alkyl; R₇ is CO₂D in which D is C_1-5-alkyl; X is halogen; structural formula VI wherein R₁-R₆ is protected OH; R₈-R₁₁ are C_1-5-alkyl; R₁₂-R₁₃ are methylidene; R₁₄-R₁₅ is oxygen; structural formula VII wherein R₁-R₄ is protected OH; R₅-R₈ are -C_1-5-alkyl; R₉-R₁₀ are methylidene; R₁₁ is CO₂D in which D is -C_1-5 alkyl; R₁₂ и R₁₃ are oxygen atom. EFFECT: improved properties of the title compounds. 17 cl, 3 dwg, 12 ex, 2 tbl