FIELD: organometallic compounds. SUBSTANCE: invention proposes the use of derivatives of cis-diamminediimidazolyl platinum dichloride of the general formula given in description. Method of synthesis involves interaction of cis-diimidazole platinum dichloride with 25% ammonium an aqueous solution at heating and intensive stirring up to complete dissolving followed by cooling and isolation of the end product. Synthesized compound shows antiproliferative and cytostatic activity and can be used in medicine, pharmaceutical and chemical industry. EFFECT: improved method of synthesis, enhanced effectiveness of compound. 2 cl, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| BISIMIDAZOLE-(1,10)-PHENENTHROLINE PLATINUM (III) DICHLORIDE SHOWING CYTOSTATIC ANTITUMOR ACTIVITY | 1995 |
|
RU2089555C1 |
| ANTITUMOR, ANTIBACTERIAL AND ANTIVIRAL PHARMACEUTICAL COMPOSITION (ITS VARIANTS) | 2006 |
|
RU2319491C1 |
| BIS-IMIDAZOLE-(1,10)-PHENANTHROLINE COPPER (II) DICHLORIDE SHOWING ANTIBACTERIAL AND ANTIBLASTIC ACTIVITY, METHOD OF ITS SYNTHESIS | 2001 |
|
RU2190616C1 |
| ANTIOXIDANT COMPOSITION (VERSIONS) | 2015 |
|
RU2593587C1 |
| COMPOSITION FOR ANTIBLASTIC THERAPY | 2001 |
|
RU2192861C1 |
| METHOD FOR PREPARATION OF COMPLEX PLATINUM (II) COMPOUND WITH HIGH-MOLECULAR N-DNA FROM SPLEEN OF CATTLE, GRADE A, SHOWING ANTICARCINOGENIC ACTIVITY | 0 |
|
SU1685944A1 |
| CIS-CHLORO-N′-((2′--TETRAHYDROFURYL)-5-FLUOROURACILATODIAMMIN- -PLATINUM (II) SHOWING ANTITUMOR ACTIVITY | 1992 |
|
RU2028301C1 |
| METHOD FOR SYNTHESIS OF PLATINUM (II) COMPLEX WITH DNA, SHOWING ANTITUMOR ACTIVITY | 0 |
|
SU1754722A1 |
| ANTI-LEUCOSIS AND ANTI-MICROBIAL COMPOSITION | 2006 |
|
RU2339376C2 |
| CYTOSTATIC AND ANTIVIRAL COMPOSITION | 1995 |
|
RU2094048C1 |
