FIELD: organic chemistry. SUBSTANCE: invention proposes an endoparasiticidic agent containing cyclic depsipeptide consisting of amino acids and hydroxycarbo- -xylic acids as ring links and 6-30 ring atoms, or its optic isomer or racemate. An agent has additionally 2-(cyclohexyl- -carbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a] -isoquinoline-4-one or 2-(cyclohexylcarbonyl)-2,3,6,7,8,12b-hexahydropyrazino-[2,1-a] -benzazepine-4-(1H)-one. Cyclic depsipeptide and indicated derivative of isoqionoline or benzazepine are taken preferably at mass ratio from 1:1 to 10:1. Activity of the proposed agent exceeds that of total activity of the known agents containing a single of two indicated components. EFFECT: enhanced effectiveness of an agent, synergetic effect. 2 tbl, 2 ex
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| ENDOPARASITICIDAL PREPARATIONS | 2001 |
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| SUSTAINED RELEASE SOLID THERAPEUTIC AGENT | 2009 |
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RU2548733C9 |
| ENDOPARASITIC AGENT | 2000 |
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| METHOD FOR SYNTHESIS OF CYCLIC DEPSIPEPTIDES | 2018 |
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RU2817013C1 |
| BENZOTHIOPHEN-2-CARBOXAMINE-5,5-DIOXIDE DERIVATIVES, METHOD OF PREPARATION THEREOF, FUNGICIDAL AND MICROBICIDAL AGENT | 1992 |
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| DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100 | 1995 |
|
RU2157803C2 |
| 2,8-DISUBSTITUTED QUINAZOLINONE DERIVATIVES OR THEIR SALTS AND PHARMACEUTICAL COMPOSITIONS BASED ON THE LATTER AFFECTING BLOOD LEVELS OF GUANOSINE AND ADENOSINE MONOPHOSPHATES | 1996 |
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| DERIVATIVES OF THIAZOLOQUINOLINE, THEIR RACEMATES OR SEPARATE ENANTIOMERS AND PHARMACEUTICALLY ACCEPTABLE HYDRATES OR SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY | 1995 |
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RU2138505C1 |
| AGENT FOR NONSYSTEMIC CONTROL OF PARASITING INSECTS | 1995 |
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RU2166253C2 |
| DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS | 1995 |
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RU2154635C2 |
