DERIVATIVES OF THIAZOLOQUINOLINE, THEIR RACEMATES OR SEPARATE ENANTIOMERS AND PHARMACEUTICALLY ACCEPTABLE HYDRATES OR SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of thiazoloquinoline of the general formula (I) where R¹ - hydrogen atom, alkyl with 1-4 carbon atoms unsubstituted or substituted with hydroxyl, methoxyl, amino-, methylamino- or dimethylamino-group or (5-methyl-2- -oxo-1,3-dioxol-4-yl)-methyl; X - direct or branched alkyl with 1-3 carbon atoms or cyclopropyl; Z a residue of formulas (a) , (b) , (c) where R⁴ means hydrogen atom, hydroxyl, a residue of the formula -NR⁷R⁸, hydroxymethyl, a residue of the formula -CH₂-NR⁷R⁸, carboxyl, methoxycarbonyl or ethoxycarbonyl being R⁷ means hydrogen atom, alkyl with 1-3 carbon atoms unsubstituted or substituted with hydroxyl, alkoxycarbonyl with 1-4 carbon atoms at an alkoxyl moiety or acyl with 1-3 carbon atoms; R⁸ means hydrogen atom or methyl; R⁵ means hydrogen atom, direct or branched alkyl with 1-3 carbon atoms or cyclopropyl; R⁶ means hydrogen atom or methyl; R³ means hydrogen atom or methyl; R² means hydrogen atom, methyl or a residue of formulas -CH= CH--COOR²-CH₂-CH₂-COOR²,-CH₂-CO-CH₃,-CH₂-CH₂-CN where R² means methyl or ethyl; B means -CH₂-, oxygen atom or direct bond. Compounds can be in the form of their racemates or separate enantiomers and as their pharmaceutically acceptable hydrates and salts. They can be used as an active component in the pharmaceutical composition showing an antibacterial activity. Invention describes pharmaceutical compositions based on compounds of the formula (I) also. EFFECT: valuable pharmacological property of compounds. 4 cl, 1 tbl, 10 ex