METHOD OF DETERMINING THROMBOPHILIA CAUSED BY RESISTANCE OF V FACTOR TO ACTIVATED PROTEIN C Russian patent published in 1999 - IPC

FIELD: clinical hematology. SUBSTANCE: to activate protein C, protein C activator is added to standard oxalate plasma and factor V-free plasma and then phospholipid membranes of platelets are added to mixture being studied. For diagnostics, one determines normalized ratio as ratio of index R_b for patient's plasma which is ratio of patient's plasma coagulation time, plasma containing no V factor and containing activated protein C to diluted patient's plasma coagulation time, to that of V factor-free plasma, and to index R_К for normal plasma. When normalized ratio is less than 0.8, results of test are regarded as positive. EFFECT: simplified procedure, improved specificity and reproducibility. 1 dwg, 3 ex