ANALOG-AGONIST OF AMYLINE, ITS PHARMACEUTICALLY ACCEPTABLE SALTS, COMPOSITION EXHIBITING PROPERTIES OF AMYLINE AGONIST Russian patent published in 1999 - IPC

Abstract RU 2130463 C1

FIELD: chemistry of proteins and peptides. SUBSTANCE: analog-agonist of amyline shows an amino acid sequence of the general formula (I): A₁-X-Asn-Thr-⁵Ala-Thr-Ala-Thr-¹⁰Gln-Arg--Leu-B₁-Asn-¹⁵Phe-Leu-C₁-D₁-E₁-²⁰F₁-G₁-Asn-H₁-Gly-25J₁-J₁-Leu-K₁-L₁-³⁰Thr-M₁-Val-Gly-Ser- -³⁵Asn-Thr-Tyr-Z where A₁-M₁ mean amino acid residues given in p. 1 of the invention claims. Composition obtained on the basis of compound of the formula (I) shows property of amyline agonist. EFFECT: agonistic property of analog. 10 cl, 2 dwg, 2 tbl, 39 ex

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RU 2 130 463 C1

Authors

Laura S.L.Gaeta

Govard Dzhons

Ehlizabet Al'Brekht

Dates

1999-05-20—Published

1992-11-19—Filed