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2 134 912

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Application

95104594/14, 1995-03-29

(22)

Actual filing date

1995-03-29

(45)

Published

1999-08-20

(72)

Inventor

Mal'Khanov V.B.Derebizova M.A.Ivanova T.S.

(73)

Holder

Ufimskij Nauchno-Issledovatel'Skij Institut Glaznykh Boleznej

METHOD FOR SIMULATING RETINA ACUTE NECROSIS OF HERPETIC ETIOLOGY Russian patent published in 1999 - IPC

Abstract RU 2134912 C1

FIELD: ophthalmology; experimental ophthalmology. SUBSTANCE: method involves injection of 0.01 ml of cellular suspension containing virus of herpes simplex, strain L2 in vitreous body of mongrel mature white mice upon instillation of one or two droplets of tetracaine hydrochloride solution in conjunctival cavity. Infectious titer of virus amounts to 106-107 TCD50/0,1 ml. Retina is analyzed three to seven days upon infection. Simulator produced in this way is most close to human disease of this kind. EFFECT: improved rate of reproduction and criticality of morphologic changes of retina.

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RU 2 134 912 C1

Authors

Mal'Khanov V.B.

Derebizova M.A.

Ivanova T.S.

Dates

1999-08-20—Published

1995-03-29—Filed

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