METHOD OF DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES, INTERMEDIATE COMPOUNDS, AND METHOD OF PREPARING INTERMEDIATE COMPOUNDS Russian patent published in 1999 - IPC

Abstract RU 2140925 C1

FIELD: chemical industry. SUBSTANCE: described is diastereoselective method of preparing optionally active cis-nucleoside and its analogues or derivatives of formula (I): wherein W,R₁,R₂•X are as defined in claim 1. Purine or pyrimidine base or its analogue or derivative is subjected to glycolization with intermediate compound of formula IIa: or IIb: wherein R₃L are as defined in claim 1 using Lewis acid in formula III: wherein R₅-R₈ are as defined in claim 1 followed by reducing R₃ glycolized purine or pyrimidine base or its analogue or derivative. EFFECT: simplified process. 32 cl, 3 ex

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RU 2 140 925 C1

Authors

Tarek Mansur

Khaolun Dzhin

Allan Kh.L.Tse

M.Arshad Siddiki

Dates

1999-11-10—Published

1992-05-20—Filed