FIELD: pharmaceutical industry. SUBSTANCE: present invention describes compounds of formula: wherein R1 is hydrogen; R2 is pyrine or pyrimidine base, analogue or derivative thereof; Z is S, S is 0 or SO2, and pharmaceutically acceptable derivatives thereof. Present invention also describes use of said compounds as antiviral agents, pharmaceutical compositions and methods of preparing said compounds. EFFECT: improved properties. 26 cl, 3 tbl
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