METHOD OF PREPARING HUMAN IMMUNOGLOBULIN FOR INTRAVENOUS ADMINISTRATION AGAINST TICK-BORNE ENCEPHALITIS Russian patent published in 1999 - IPC

FIELD: medicine, immunology. SUBSTANCE: invention relates to the production of specific immunoglobulin for an intravenous administration. Method involves the isolation of the specific immunoglobulin fraction using ethanol at low temperatures. Donor plasma is fractionated up to the stage of immunoglobulin dried precipitate preparing which is dissolved in 2% glucose solution and pepsin is added. After proteolysis an enzyme is removed with aluminium hydroxide, pH value of solution is brought about to 6.5-7.5 followed by sterilizing filtration and settling the preparation to form nonstable proteins precipitate. The precipitate is removed by centrifugation at 6000 rev/min and the end product is obtained after sterilizing filtration. Obtained human immunoglobulin against tick-borne encephalitis can be used for an intravenous administration. EFFECT: low an anticomplementary activity of the preparation. 1 ex