DERIVATIVES OF PYRIDONE CARBOXYLIC ACID, METHODS OF THEIR SYNTHESIS, ANTITUMOR AGENT AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyridone carboxylic acid of the formula (I) where R₁ is hydrogen, halogen atom, lower alkyl or phenyl substituted with halogen atom; R₂ is carboxyl group or group capable to be converted to carboxyl group; R₃ is hydrogen atom, amino-group, halogen atom or lower alkyl possibly substituted with halogen atom; A is CH; m = 1 or 2; Y is removable group or group of the formula ; Z is H, lower alkyl or group capable to be converted to hydrogen atom; R₅ is Y, halogen atom, lower alkoxy-group, lower alkylthio-group or lower alkyl possibly substituted with halogen atom; n = 0 or 1; p = 1 or 2. Compounds of the formula (I) can be used as effective components of antitumor and anticancer agents. EFFECT: valuable pharmacological properties of compounds. 24 cl, 12 dwg, 10 tbl, 42 ex