DERIVATIVES OF 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDINE-2(1H)-ONE, PHARMACEUTICAL COMPOSITION AND DERIVATIVES OF 1,6-NAPHTHYRIDINE-2(1H)-ONE Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 5-substituted-3-oxadiazolyl-1,6-naphthyridine-2(1H)-one of the formula (I) where Het is oxaziazolyl; R¹ is H, lower alkyl, cyclo-lower alkyl, trifluoromethyl, lower alkenyl, lower alkynyl, lower alkoxy-group, lower alkoxy-lower alkyl, hydroxy-lower alkyl, substituted or unsubstituted aryl group or unsubstituted heteroaromatic group; R² is H, lower alkyl, lower cycloalkyl, cyclo-lower alkylmethyl, lower alkenyl, cyclo-lower alkenyl, lower alkynyl, substituted to unsubstituted aryl group or unsubstituted heteroaromatic group. Invention relates to also pharmaceutically acceptable additive acid salts that show highly selective affinity to benzodiazepine receptors and they are especially useful, for example, as a psychoanaleptic agent or a medicinal agent for treatment of dysmnesia, senile disease or Alzheimer's disease. Invention describes also a pharmaceutical composition and intermediate compounds used in synthesis of compounds of the formula (I). EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. 7 cl, 31 tbl, 370 ex