METHOD OF PREPARING 3-ETHYL-5-METHYL ESTER OF 2-[2-N-(PHTHALIMIDO)ETHOXYMETHYL]- 4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID Russian patent published in 2000 - IPC

Abstract RU 2161156 C1

FIELD: organic chemistry. SUBSTANCE: described is method of preparing 3-ethyl-5-methyl ester of 2-[2-(N-phthalimido)ethoxymethyl-4-(2-chlorphenyl)-1,4-dihydro-6- methyl-3,5-pyridinedicaroxylic acid of formula I: by reacting 2- chlorobenzaldehyde with 4-[2-(N-phthalimido)ethoxyacetoacetic acid ethyl ester in isopropyl alcohol solvent using pyridine, piperidine or salt s thereof as catalyst at temperatures from 25 C 35 C to gibe benzylidine derivative of 4-[2- (N-phthalimido)aceto acetic acid ethyl ester which is reacted with methylaminoprotonate added in portions to acetic acid at temperatures from 35 to 55 C to give product. EFFECT: more efficient preparation method. 3 cl, 1 dwg, 1 ex

Similar patents RU2161156C1

Title	Year	Author	Number
METHOD OF PREPARING MONOBENZOSULFONATE OF 2-[(2- AMINOETHOXY) METHYL -4- (2-CHLOROPHENYL)-1,4-DIHYDRO-6- METHYL]-3,5-PYRIDINE DICARBOXYLIC ACID 3-ETHYL-5-METHYL ESTER	1999	Shrikkhande Atul Anant Doshi Madkhukant Mansukkhlal Modi Shirish Bkhagvanlal	RU2142942C1
METHOD OF SYNTHESIS OF 3-ETHYL-5-METHYL-2-(2-AMINOETHOXYMETHYL)- -4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDRO-3,5-PYRIDINE DICARBO-XYLATE AND BENZENESULFOACID SALT (AMLODIPINE BEZYLATE)	1998	Bozhing Daniehl' Laks Kovan'I D'Erd'I Shimig D'Jula Kratsnai D'Erd' Blashko Gabor Tomp Peter Nad' Kalman Donat Veretskei D'Erd'I Nemet Gabor Nemet Norbert	RU2163597C2
METHOD OF PRODUCING DERIVATIVES OF 1,4-DIHYDROPYRIDINE OR ACID-ADDITIVE SALTS THEREOF	0	Simon Frazer Kempbell Piter Edvard Kross Dzhon Kendrik Stabbz	SU1238730A3
METHOD FOR PRODUCTION OF 3-ETHYL-5-METHYL-(±)2/(2-AMINOETHOXY)-METHYL-4-(2-CHLOROPHENYL)-1,4- -DIHYDRO-6-METHYL-3,5-PYRIDINE CARBOXYLATE MONOBENZOATE AND INTERMEDIATE FOR THEM	1993	Borut Furlan[Si] Anton Chopar[Si] Alenka Jerikha[Si]	RU2105759C1
	0	Khorst Mejer Fridrikh Bossert Vulf Fater Kurt Shtepel	SU468416A3
	0	Khorst Mejer Fridrikh Bossert Vulf Fater Kurt Shtepel	SU464111A3
METHOD OF PREPARING AMLODIPINE BEZYLATE	1999	Ramesh Kumar	RU2173685C2
DIHYDROPYRIDINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF	1992	Paolo Kotstsi[It] Marija Menikhinkheri[It] Laura Kapolongo[It] Nikola Mongelli[It]	RU2086548C1
	0	Fridrikh Bossert Khorst Mejer Vulf Fater	SU515452A3
AMLODIPIN BENZOLSULFONATE PREPARATION METHOD	2002	Vijas Ashok	RU2221784C1

RU 2 161 156 C1

Authors

Atul Anant Shrikkhande

Madkhukant Makhsukkhlal Doshi

Shirish Bkhagvanlal Modi

Dates

2000-12-27—Published

1999-06-23—Filed