DIHYDROPYRIDINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1997 - IPC

Abstract RU 2086548 C1

FIELD: organic chemistry. SUBSTANCE: product: dihydropyridine derivatives of the formula (I) where: Het - the group or ; A means direct bond, -CH2-,-CH2-CH2- or when Het - the group symbol A can mean also the group -CH=CH-; R - hydrogen or halogen atom, C1-C3-alkyl or C1-C3-alkoxy-group; one of R3 and R4 means C1-C3-alkyl possibly omega-substituted with C1-C3-alkoxy-group and other independently of the first - C1-C3-alkyl, possibly substituted with C1-C3-alkoxy-group or the group ; R5 - hydrogen atom or C1-C6-alkyl possibly substituted with the group -N-RcRd; one of R1 and R2 means the group -OR' where R' means C1-C6-alkyl possibly substituted with C1-C3-alkoxy-group or cyano-group and other means independently of the first: a) C1-C3-alkyl; b) group -OR'; c) group ψ or d) group ORIV where RIV - hydrogen atom or substituent taken from (-(CH2)m-VH=CH-Ph,), (), () and (). Synthesized compounds can be used in medicine as agents enhancing antitumor action. EFFECT: improved method of synthesis. 8 cl

Similar patents RU2086548C1

Title Year Author Number
N-IMIDAZOLYL DERIVATIVES OF THE SUBSTITUTED ALKOXYIMINOTETRAHYDRONAPHTHALENES OR CHROMANES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF THROMBOXANE ANTAGONIST AND THROMBOXANE SYNTHASE INHIBITOR 1992
  • Paolo Kotstsi[It]
  • Antonio Dzhiordani[It]
  • Arsenia Rossi[It]
  • Patritsia Salvati[It]
  • Korrado Ferti[It]
RU2083566C1
N-IMIDAZOLYL-DERIVATIVES OF THE SUBSTITUTED INDOLE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION 1992
  • Paolo Kotstsi[It]
  • Antonio Pillan[It]
  • Mauritsio Pulichi[It]
  • Patritsija Sal'Vati[It]
  • Anzhelo Daniehle Volpi[It]
RU2073669C1
OXOPROPANT-NITRILE DERIVATIVES OF CONDENSED PYRAZOLE OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSTIMULATING ACTIVITY, AND PHARMACEUTICAL COMPOSITION 1990
  • Zhanfederiko Doria[It]
  • Anna Marija Izetta[It]
  • Mario Ferrari[It]
  • Domeniko Tritsio[It]
RU2109735C1
METHOD OF SYNTHESIS OF THE SUBSTITUTED BENZOFURAN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS 1993
  • Andzhelo Bedeski[It]
  • Val'Ter Kabri[It]
  • Ilaria Kandiani[It]
  • Sil'Vija De Bernardinis[It]
  • Marchello Marchi[It]
RU2098415C1
DERIVATIVES OF UREA, METHOD OF SYNTHESIS OF UREA DERIVATIVES, PHARMACEUTICAL COMPOSITION SHOWING INHIBITING ACTIVITY WITH RESPECT TO COA : CHOLESTEROL ACYLTRANSFERASE 1992
  • Paolo Kotstsi[It]
  • Daniele Fanchelli[It]
  • Dino Severino[It]
  • Augusto Chiari[It]
  • Dzhiankarlo Gizelli[It]
RU2090555C1
METHOD FOR PRODUCTION OF DERIVATIVES OF ERGOLINE 1991
  • Serdzho Mantegani[It]
  • Gabriehlla Trakvandi[It]
  • Titsiano Band'Ero[It]
  • Ehntso Brambilla[It]
RU2074857C1
17$$$-SUBSTITUTED 3-CARBOXYSTEROIDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 1992
  • Akille Pantseri[It]
  • Marchella Nesi[It]
  • Ehnriko Di Salle[It]
RU2104283C1
COMPOUNDS OF CEPHEM AND ITS PHARMACEUTICALLY AND VETERINARY ACCEPTABLE SALTS AND METHOD FOR THEIR PRODUCTION 1990
  • P'Erluidzhi Bissolino[It]
  • Marko Alpedzhiani[It]
  • Ehttore Perrone[It]
  • P'Erdzhuzeppe Oretstsi[It]
  • Dzhuzeppe Kassinelli[It]
  • Dzhovanni Francheski[It]
RU2074186C1
ARYLOXYALKENYLENE DERIVATIVES OF AMINES OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTIDEPRESSANT ACTIVITY 1990
  • P'Ero Melloni[It]
  • Filippe Dostert[Fr]
  • Arturo Della Torre[It]
  • Al'Berto Bonsin'Ori[It]
RU2007386C1
3-DEOXYMANNOSEAMINE DERIVATIVE, A METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITING EFFECT ON VESSEL AND METASTASIS DEVELOPMENT 1992
  • Nikola Mongelli[It]
  • Al'Berto Bardzhiotti[It]
  • Nuchchia Oneto[It]
  • Kristina Dzheroni[It]
RU2099333C1

RU 2 086 548 C1

Authors

Paolo Kotstsi[It]

Marija Menikhinkheri[It]

Laura Kapolongo[It]

Nikola Mongelli[It]

Dates

1997-08-10Published

1992-09-18Filed