DERIVATIVES OF BENZOTHIAZINE DIOXIDE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING INHIBITORY ACTIVITY OF ENDOTHELIN RECEPTOR AND METHOD OF INHIBITION OF ENDOTHELIN RECEPTOR Russian patent published in 2001 - IPC

FIELD: organic chemistry of heterocyclic compounds, pharmacy. SUBSTANCE: invention describes novel derivatives of benzothiazine dioxide of the general formula (1) where R₂ means the group of the formula (2) or alkyl with 1-7 carbon atoms where each of R_a and R_c means from 1 to 5 substituents and R_b means from 1 to 4 substituents taken independently among the group including hydrogen, chlorine atom, methylenedi- -hydroxy-group, ethylenedihydroxy-group, groups OR and OCH₂OR where R means hydrogen atom, alkyl with 1-6 carbon atoms or phenyl; R_d means groups CO₂R, SO₃R, CONRR₁ where R has the above indicated value and R₁ has value given for radical R; n = 0-2; _ _ _ means ordinary or double bond; X means (CH₂)_n or S(O)_n, where n has the above indicated value or their pharmaceutically acceptable salts of acid or base addition. Invention relates to also pharmaceutical composition based on given compounds showing inhibitory activity of endothelin and method of inhibition of endothelin receptors. Proposed heterocyclic compounds can be used as active components in pharmaceutical compositions. EFFECT: broadened arsenal of heterocyclic compounds, valuable properties of compounds. 7 cl, 1 tbl, 56 ex