ARYLTHIOCOMPOUNDS, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel arylthiocompounds of the general formula (I) where R¹ and R² are independent each of other and mean hydrogen, halogen atom, alkyl with 1-6 carbon atoms, alkoxy-group with 1-6 carbon atoms, cycloalkyl-group with 3-6 carbon atoms, hydroxyl, cyano-group, phenyl-(CR⁵R⁶)_m-group; Het is or they in common mean oxo-group or methylenedihydroxy-group where R³ and R⁴ are independent each of other and mean hydrogen atom, alkyl with 1-6 carbon atoms, cycloalkyl with 3-6 carbon atoms, phenyl-(CR⁵R⁶)_m; R⁵ and R⁶ are independent each of other and mean hydrogen atom, alkyl with 1-6 carbon atoms, hydroxyl, carboxyl, amino-group, group CONH₂ or cyano-group; Het is cyclic or bicyclic ring with 4-10 atoms and 1-4 of that mean oxygen, sulfur or nitrogen atoms; m = 0, 1 or 2; X means groups: (O)=C-NR⁴Z, -(O)=C-Z, -(NOH)=C-Z or SO₂NR⁴Z where Z is halogen atom, substituted alkyl with 1-6 carbon atoms, groups CO, alkyl with 1-6 carbon atoms in alkyl moiety, cycloalkyl-(CR⁵CR⁶)_m with 3-6 carbon atoms in cycloalkyl moiety, phenyl-(CR⁵CR⁶)_m where R⁵, R⁶ and m have the above indicated value and R⁴ has the above indicated value; Y is hydrogen atom or group SZ if n = 1 or simple bond if n = 2 being Z has the above indicated value; n = 1 or 2 being indicated residues of alkyl, cycloalkyl, phenyl and Het can be substituted with 1-3 residues among the group involving halogen atom, alkyl with 1-6 carbon atoms, alkoxy-group with 1-6 carbon atoms, trifluoromethyl-group, hydroxyl, cyano-group, nitro-group, NR³R⁴, NR³COR⁴, CO₂ where R³ is NH(NH)=C-NH₂, CONR³R⁴, S(O)_mR³, PO₄(R³)₃, S(O)_mNR³R⁴, COR³ where R³, R⁴ and m have the above indicated value, and their pharmaceutically acceptable salts and solvates. These compounds show antibacterial and antiviral activity and can be used for treatment of patients with bacterial and viral infections. Invention describes also method of treatment and pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds indicated above, valuable curative and medicinal properties. 47 cl, 18 ex