COMPOUNDS PROMOTING GROWTH HORMONE RELEASE Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel compound of the general formula (I): A-B-C-D-E-(-F)_p where p = 0 or 1; A means imidazolyl-C_1-6-alkanoic acid, imidazolyl-C_1-6-alkenoic acid, amino-C_1-6-alkanoic acid, L- or D-α-amino acid taken among the group consisting of H-His, H-D-Ala, H-Aib; B means D-Trp, D-2-Nal or D-Phe; C means Ala or Gly; D means Trp or N-aralkylglycine; E means D-Phe if p = 1 or E means -NH-CH-(CH₂R)³-CO-R⁴ or -NH-CH-(CH₂R)³-CH-R⁴ if p = 0 where R³ means phenyl and R⁴ means -N(R⁵)⁶ where each R⁵ and R⁶ means independently hydrogen atom or lower alkyl; F means -NH-CH(R¹⁰)-CH₂)_v-R⁷- if p = 1 where v is a whole number from 1 to 8 and R⁷ means -N(R⁸)-R⁹) where each R⁸ and R⁹ means independently hydrogen atom; R¹⁰ means -H, -COOH, CO-R¹¹ or CH₂- where R¹¹ means -N(R¹²)-(R¹³) where each R¹² and R¹³ is hydrogen atom independently under condition that at least one amide bond between A and B, B and C, C and D, D and E or between K and F is substituted with aminomethylene if p = 1; or E means -NH-CH-(CH₂-R³)CH₂-R⁴ if p = 0; or R¹⁰ means CH₂-R¹¹ if p = 1; or pharmaceutically acceptable salt of this compound. Compounds show the enhanced resistance to proteolytic cleavage by enzymes due to substitution of amide bond (-CO-NH-) with aminomethylene one (-CH₂NH-) or by addition of N-aralkylglycine. Invention describes also pharmaceutical composition used for stimulation of growth hormone release from hypophysis. EFFECT: new compound indicated above, valuable properties. 15 cl, 19 ex