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2 168 991

(13)

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IPC

(21) (22)

Application

2000118204/14, 2000-07-13

(24)

Start date

2000-07-13

(22)

Actual filing date

2000-07-13

(45)

Published

2001-06-20

(72)

Inventor

Ol'Binskaja L.I.Khapaev B.A.Ekshatjan I.M.

(73)

Holder

Moskovskaja Meditsinskaja Akademija Im. I.M. SechenovaOl'Binskaja Ljubov' Il'InichnaKhapaev Bashir AlimdzhasharovichEkshatjan Irina Mikhajlovna

METHOD OF SELECTION OF PATIENTS WITH HYPERTENSIA FOR TREATMENT WITH NEBIVOLOL Russian patent published in 2001 - IPC

Abstract RU 2168991 C1

FIELD: medicine, cardiology, pharmacy. SUBSTANCE: method involves assay of platelet guanylate cyclase activity stimulated with protoporphyrin IX. Monotherapy with nebivolol is prescribed if its activity is below 250 pmole/ /min/mg and nebivolol is combined with hydrochlorothiazide as an other antihypertension agent if enzyme activity is above 250 pmole/min/mg. Method provides differentiating effect on vasodilating function of endothelium tissue. EFFECT: decreased time for hypotensive effect attainment. 1 tbl, 2 ex

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RU 2 168 991 C1

Authors

Ol'Binskaja L.I.

Khapaev B.A.

Ekshatjan I.M.

Dates

2001-06-20—Published

2000-07-13—Filed